PMID-9189903[] Subthalamic stimulation elicits hemiballismus in normal monkey.
- the effects of stimulation on normal waking primates has never been evaluated (doh!)
- In the normal monkey, HFS appears reversibly to incapacitate the STN and allow the emergence of involuntary proximal displacements, due to disinhibition of the thalamo-cortical pathway
- in MPTP-treated monkey HFS buffers STN activity and alleviates akinesia and rigitity by reducing inputs to the internal segment of the globus pallidus. (STN output is excitatory) (or so the theory at the time goes)
- perhaps i will need to buy this article ;(
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