PMID-11250009[0] Sleep and memory: a molecular perspective.
- inhibition of protein synthesis is most effective if it occurs at a time post-training when rapid eye movement (REM) sleep is required for memory consolidation
- The neurochemical changes that occur across sleep/wake states, especially the cholinergic changes that occur in the hippocampus during REM sleep, might provide a mechanism by which sleep modulates specific cellular signaling pathways involved in hippocampus-dependent memory storage.
-
- REM sleep could influence the consolidation of hippocampus-dependent long-term memory if it occurs during windows that are sensitive to cholinergic or serotonergic signaling.
- PKA activation seems important to hippocampal long-term memory
- NMDA affects PKA through Ca2+ to adenyl cyclase
- 5-HT_1A receptor negatively coupled to adenyl cyclase (AC)
- 5-HT concentrations go down in hippocampus during sleep ?
____References____
[0] Graves L, Pack A, Abel T, Sleep and memory: a molecular perspective.Trends Neurosci 24:4, 237-43 (2001 Apr) |
|