PMID-20505125[0] Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity.
- Hypothesis: disorder in the STN leads to parkinsonian symptoms (tremor, akinesia).
- finger tapping test.
- Irregular DBS was less effective than regular DBS at eliminating bradykinesia.
- computational model: this is because there are more transmission errors at thalamic output neurons.
- computational model possibly fluffy to keep conclusion from being too short?
- cf. [1][2] -- which includes an irregular stimulation protocol (at longer timescales).
____References____
[0] Dorval AD, Kuncel AM, Birdno MJ, Turner DA, Grill WM, Deep brain stimulation alleviates parkinsonian bradykinesia by regularizing pallidal activity.J Neurophysiol 104:2, 911-21 (2010 Aug) |
[1] Rosin B, Slovik M, Mitelman R, Rivlin-Etzion M, Haber SN, Israel Z, Vaadia E, Bergman H, Closed-loop deep brain stimulation is superior in ameliorating parkinsonism.Neuron 72:2, 370-84 (2011 Oct 20) |
[2] Santos FJ, Costa RM, Tecuapetla F, Stimulation on demand: closing the loop on deep brain stimulation.Neuron 72:2, 197-8 (2011 Oct 20) |
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