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[0] Rózsa B, Katona G, Kaszás A, Szipöcs R, Vizi ES, Dendritic nicotinic receptors modulate backpropagating action potentials and long-term plasticity of interneurons.Eur J Neurosci 27:2, 364-77 (2008 Jan)

[0] Buonomano DV, Merzenich MM, Cortical plasticity: from synapses to maps.Annu Rev Neurosci 21no Issue 149-86 (1998)

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ref: -0 tags: synaptic plasticity LTP LTD synapses NMDA glutamate uncaging date: 08-11-2020 22:40 gmt revision:0 [head]

PMID-31780899 Single Synapse LTP: A matter of context?

  • Not a great name for a thorough and reasonably well-written review of glutamate uncaging studies as related to LTP (and to a lesser extent LTD).
  • Lots of refernces from many familiar names. Nice to have them all in one place!
  • I'm left wondering, between CaMKII, PKA, PKC, Ras, other GTP dependent molecules -- how much of the regulatory network in synapse is known? E.g. if you pull down all proteins in the synaptosome & their interacting partners, how many are unknown, or have an unknown function? I know something like this has been done for flies, but in mammals - ?

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ref: -2012 tags: octopamine STDP locust LTP LTD olfactory bulb date: 03-11-2019 18:59 gmt revision:5 [4] [3] [2] [1] [0] [head]

PMID-22278062 Conditional modulation of spike-timing-dependent plasticity for olfactory learning.

  • Looked at the synapes from the Muschroom body (Kenyon cells, sparse code) to the beta-lobe (bLN) in locusts.
  • Used in-vivo dendrite patch, sharp micropipette.
  • Found that, with a controlled mushroom body extracellular stim for plasticity induction protocol at the KC-> bLN synapese, were able to get potentiation and depression in accord with STDP.
  • This STDP became pure depression in the presence of octopamine
  • See also / supercedes: Synaptic Learning Rules and Sparse Coding in a Model Sensory System Luca A. Finelli ,Seth Haney, Maxim Bazhenov, Mark Stopfer, Terrence J. Sejnowski 2008

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ref: RAzsa-2008.01 tags: nAChR nicotinic acetylchoine receptor interneurons backpropagating LTP hippocampus date: 10-08-2008 17:37 gmt revision:0 [head]

PMID-18215234[0] Dendritic nicotinic receptors modulate backpropagating action potentials and long-term plasticity of interneurons.

  • idea: nAChRs are highly permeable to Ca+2, LTP is dependent on Ca2+, so they tested nAChR -> LTP in interneurons of rat hippocampus using whole-cell electrophysiology and 2-photon imaging.
  • Here we show that precisely timed activation of dendritic α7-nAChRs boosts the induction of LTP by excitatory postsynaptic potentials (EPSPs) and synaptically triggered dendritic Ca2+ transients.
  • suggest that this rapid (ionotropic) method of memory encoding and retrieval via LTP/D facilitated by acetylcholine.
  • I haven't read much of the article, since it is much out of my field of experience.

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ref: Buonomano-1998.01 tags: cortical plasticity learning review LTD LTP date: 10-07-2008 03:27 gmt revision:1 [0] [head]

PMID-9530495[0] Cortical plasticity: from synapses to maps

  • focuses on synaptic plasticity as the underlying mechanism of behavior-dependent cortical maps/representations.
  • "within limits, the cortex can allocate cortical area in a use-dependent manner"
  • synaptic plasticity -> STDP via NMDA, etc.
    • demonstrated with intracellular recordings of cat M1 & simultaneous stimulation of the ventrolateral thalamus & intracellular depolarization. Facilitation was short lasting and not present in all neurons.
    • demonstrated in rat auditory cortex / recording in layer 2/3 , stimulate layer 2/3 & White matter/6.
    • review of Ca+ hypothesis of LTP/LTD balance: if the Ca+ influc is below a threshold, LTD occurs; if it is above a certain threshold, LTP.
      • not sure how long LTD has been demonstrated -- 15 min?
  • cellular conditioning = direct induction of plastic changes in the selective responses of individual neurons in vivo as a result of short-term conditioning protocols. this is what we are interested in, for now.
    • this review does not explicitly deal with BG-DA / ACh reinforcement, only timing dependent plasticity, in visual and auditory cortex.
  • cortical plasticity:
    • talk about the revealing/unmasking of hidden responses when sections of cortex are deafferented or digits were amputated.
    • talk about training-based approaches: training increases cortical representation of a sensory modality / skill/ etc. The cortex can differentially 'allocate' area in a use-dependent manner throughout life.
    • cortical map changes are not reflected by changes in thalamic somatotopy.

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