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ref: -2010 tags: neural signaling rate code patch clamp barrel cortex date: 03-18-2021 18:41 gmt revision:0 [head]

PMID-20596024 Sensitivity to perturbations in vivo implies high noise and suggests rate coding in cortex

  • How did I not know of this paper before.
  • Solid study showing that, while a single spike can elicit 28 spikes in post-synaptic neurons, the associated level of noise is indistinguishable from intrinsic noise.
  • Hence the cortex should communicate / compute in rate codes or large synchronized burst firing.
    • They found large bursts to be infrequent, timing precision to be low, hence rate codes.
    • Of course other examples, e.g auditory cortex, exist.

Cortical reliability amid noise and chaos

  • Noise is primarily of synaptic origin. (Dropout)
  • Recurrent cortical connectivity supports sensitivity to precise timing of thalamocortical inputs.

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ref: Butovas-2007.04 tags: Butovas Schwarts ICMS stimulation rat barrel cortex date: 01-03-2012 06:55 gmt revision:2 [1] [0] [head]

PMID-17419757[0] Detection psychophysics of intracortical microstimulation in rat primary somatosensory cortex.

  • headposted rats, ICMS to barrel cortex
  • single pulse threshold = 2 nC, around the threshold for evocation of short-latency action potentials near an electrode.
  • one pulse saturated at 80% correct.
  • multiple pulses had a higher rate, though this saturated at 15 pulses.
  • double pulse optimal in terms of power / discrimination.

____References____

[0] Butovas S, Schwarz C, Detection psychophysics of intracortical microstimulation in rat primary somatosensory cortex.Eur J Neurosci 25:7, 2161-9 (2007 Apr)