Temporally Coordinated Deep Brain Stimulation in the Dorsal and Ventral Striatum Synergistically Enhances Associative Learning
- Monkeys had to learn to associate an image with one of 4 reward targets.
- Fixation period, movement period, reward period -- more or less standard task.
- Blocked trial structure with randomized associations + control novel images + control familiar images.
- Timed stimulation:
- Nucleus Accumbens during fixation period
- Shell not core; non-hedonic in separate test.
- Caudate (which part -- targeting?) during feedback on correct trials.
- Performance on stimulated images improved in reaction time, learning rate, and ultimate % correct.
- Small non-significant improvement in non-stimulated novel image.
- Wonder how many stim protocols they had to try to get this correct?
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