PMID-12023310[0] Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease.
- Key finding: Synchronized HFOs (high-frequency oscillations, 15-30Hz here) between STN neurons were observed in 28 out of 37 pairs in five patients who had tremor in the operating room and none of 45 pairs in three patients who did not.
- Active movement suppressed synchronized HFOs in three out of five pairs of neurones, independent of changes in firing rate.
- Dopamine treatment also supressed LFP HFOs, synchrony between STN neuron pairs, and synchrony between tremor cells.
- They suggest that STN is diseased ... however, STN does not receive a great number of SNc projections, hence the pathology may merely bre reflective of upstream structures.
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[0] Levy R, Ashby P, Hutchison WD, Lang AE, Lozano AM, Dostrovsky JO, Dependence of subthalamic nucleus oscillations on movement and dopamine in Parkinson's disease.Brain 125:Pt 6, 1196-209 (2002 Jun) |
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