PMID-16973296[0] Subthalamic nucleus neurones in slices from MPTP-lesioned mice show irregular, dopamine-reversible firing pattern changes, but without synchronous activity
- loss of dopamine in parkinson-model rats (not MPTP!) induces synchronized low-frequency oscillatory burst-firing in subthalamic nucleus neurons
- MPTP mice, neurons fire slower, and more irregularly
- only dopamine varied (increased) firing rate.
- the STN & GP are insufficient to generate the abberant firing patterns in the STN, by itself - the disease is more than just dopamine depletion.
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[0] Wilson CL, Cash D, Galley K, Chapman H, Lacey MG, Stanford IM, Subthalamic nucleus neurones in slices from 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned mice show irregular, dopamine-reversible firing pattern changes, but without synchronous activity.Neuroscience 143:2, 565-72 (2006 Dec 1) |
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