What are the concentrations of the monoamines in the brain? (Purpose: estimate the required electrochemical sensing area & efficiency)
- Dopamine: 100 uM - 1 mM local, extracellular.
- PMID-17709119 The Yin and Yang of dopamine release: a new perspective.
- Serotonin (5-HT): 100 ng/g, 0.5 uM, whole brain (not extracellular!).
- Norepinephrine / noradrenaline: 400 nm/g, 2.4 uM, again whole brain.
- PMID-11744005 An enriched environment increases noradrenaline concentration in the mouse brain.
- Also has whole-brain extracts for DA and 5HT, roughly:
- 1200 ng/g DA
- 400 ng/g NE
- 350 ng/g 5-HT
- So, one could imagine ~100 uM transient concentrations for all 3 monoamines.
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