PMID-25705966 Robust and fragile aspects of cortical blood flow in relation to the underlying angioarchitecture.
- "The penetrating arterioles that connect the pial network to the subsurface network are bottlenecks to flow; occlusion of even a single penetrating arteriole results in the death of a 500 μm diameter cylinder of cortical tissue despite the potential for collateral flow through microvessels."
- The pioneering work of Fox and Raichle [7] suggest that there is simply not enough blood to go around if all areas of the cortex were activated at once.
- There is strong if only partially understood coupling between neuronal and vascular dysfunction [15]. In particular, vascular disease leads to neurological decline and diminished cognition and memory [16].
- A single microliter of cortex holds nearly one meter of total vasculature length wow! PMID-23749145
- Subsurface micro vasculature (not arterioles or venules) is relatively robust to occlusion; figure 4.
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