Single-impulse panoramic photoacoustic computed tomography of small-animal whole-body dynamics at high spatiotemporal resolution
- Used Q-switched Nd:YAG and Ti:Sapphire lasers to illuminate mice axially (from the top, through a diffuser and conical lens), exciting the photoacuostic effect, from which they were able to image at 125um resolution a full slice of the mouse.
- I'm surprised at their mode of illumination -- how do they eliminate the out-of-plane photoacoustic effect?
- Images look low contrast, but structures, e.g. cortical vasculature, are visible.
- Can image at the rep rate of the laser (50 Hz), and thereby record cardiac and pulmonary rhythms.
- Suggest that the photoacoustic effect can be used to image brain activity, but spatial and temporal resolution are limited.
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