PMID-19109506 Parkinsonian beta oscillations in the external globus pallidus and their relationship with subthalamic nucleus activity.
- Rat 6-OHDA.
- On rate model: Although synchronization of GP unit activity increased by almost 100-fold during beta oscillations, the mean firing rate of GP neurons decreased compared with controls.
- Synchronized firing persisted across different brain states, suggesting hardwiring.
- GP and STN are frequency aligned but phase skewed.
- Lateral inhibition in GP seems essential / see model.
- Suggest that GPe / STN could generate oscillations that propagate to the rest of the BG.
- But then why is the cortex required?
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