http://www.neuroanatomy.wisc.edu/virtualbrain/BrainStem/06Olive.html
- source of long-latency climbing fibers
- projects to contralateral cerebellum.
- destruction of IO = destruction of contralateral cerebellum.
- conversely, removal of one cerebellar hemesphere -> atropy of contralateral IO.
- the climbing fibers of the IO run through the inferior cerebellar peduncle.
- according to {115}, the motor cortex projects to the inferior olive. from wikipedia: many collaterals from the reticular formation and from the pyramides enter the inferior olivary nucleus.
- PMID-16527758 the afferents from the DCN to the IO are involved in feedback control of learning & feedback control of complex/simple spike activity in purkinje cells.
- PMID-5967023 Afferent connexions to single units in the inferior olive of the cat
- the immediate response to stimulation of the limb nerves was always excitation of the olivary units, sometimes which was followed by a slent period of inhibition.
- single units in the olive could be excited by moving single hairs on the foot or be stroking the surface of the limbs.
- stimulation of the ipsilateral caudate nucleus caused firing in IO units with a latency of 1.0 20ms
- PMID-5340538 http://hardm.ath.cx:88/pdf/AfferentsInferiorOlive1967.pdf
- there seem to be two classes of olive units: those that respond with low latency to motor cortex stimulation and spinal pathways (these have a high degree of topographic specificity), and those which respond with higher latency to stimulation of the caudate (with lower topographic specificity).
- climbing fibers fire more of a wave than an isolated AP.
- red nucleus and VA/VL thalamus are innervated from the deep cerebellar nuclei, which is inhibited by purkinje cells.
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